J&J seeks OK for first drug against resistant TB

FILE- In this Monday, July 17, 2006 file photo, a technician at Ortho-Clinical Diagnostics Inc., a Johnson & Johnson company, works in a "sterile filling" room at the plant in Raritan, N.J. Johnson & Johnson said Monday, July 2, 2012, that it is seeking U.S. approval for the first new type of medicine to fight deadly tuberculosis in more than four decades AP Photo/Mike Derer, File)

FILE- In this Monday, July 17, 2006 file photo, a technician at Ortho-Clinical Diagnostics Inc., a Johnson & Johnson company, works in a "sterile filling" room at the plant in Raritan, N.J. Johnson & Johnson said Monday, July 2, 2012, that it is seeking U.S. approval for the first new type of medicine to fight deadly tuberculosis in more than four decades AP Photo/Mike Derer, File)

TRENTON, N.J. (AP) ? Johnson & Johnson said Monday that it is seeking U.S. approval for the first new type of medicine to fight deadly tuberculosis in more than four decades.

The experimental drug, called bedaquiline, also would be the first medicine specifically for treating multi-drug-resistant tuberculosis. That's an increasingly common form in which at least two of the four primary TB drugs don't work.

Tuberculosis, caused by bacterial infection of the lungs and other body areas, is the world's No. 2 killer of adults among infectious diseases.

J&J's Janssen Research & Development unit created the drug, which was tested in several hundred patients with multidrug-resistant tuberculosis in two mid-stage studies lasting for six months. Some patients were studied for about 1 1/2 years.

The company this fall is to begin late-stage testing that will compare bedaquiline to dummy pills over nine months in about 600 patients; each will also take six other drugs that are the standard treatments for tuberculosis. That study is aimed at seeing whether treatment for resistant tuberculosis can be reduced to nine months from the current 18 to 24 months recommended by the World Health Organization.

Roughly one-third of the world's population is estimated to be infected with the bacteria causing tuberculosis. It remains latent in most people for many years but can be activated by another infection or serious health problem.

TB is rare in the U.S. but kills about 1.4 million people a year worldwide, with about 150,000 of those succumbing to the increasingly common multidrug-resistant forms.

Janssen's head of infectious diseases, Dr. Wim Pays, said the company will also apply for approval of bedaquiline in other countries where TB is very common.

The disease is a serious problem in developing countries because it takes so long to cure and many patients stop taking their pills once they begin to feel better. That helps bacteria still alive in the patient to develop resistance to the medicines already taken, making future treatment much more difficult.

J&J shares rose 44 cents to close at $68, just shy of their 52-week high of $68.05 set almost a year ago.

___

Linda A. Johnson can be followed at http://twitter.com/LindaJ_onPharma

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2012-07-02-Johnson%20and%20Johnson-TB%20Drug/id-dcf35c2f7f4e49fab9001886185862ba

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Nokia chairman says company has a Windows Phone 'contingency plan' after all

So much for no plan B. A little less than a year after Nokia US' Chris Weber proclaimed rather bluntly, "the reality is if we are not successful with Windows Phone, it doesn't matter what we do," Nokia's chairman Risto Siilasmaa reportedly said in an interview that the company does, indeed, have a "contingency plan," should Windows Phone 8 falter. What precisely such a plan might entail, however, we're not really sure. Still, the F-Secure founder naturally remains positive about the future of Microsoft's mobile operating -- and Nokia head honcho Stephen Elop, whose leadership has been "good and transparent," according to Siilasmaa.

Nokia chairman says company has a Windows Phone 'contingency plan' after all originally appeared on Engadget on Mon, 02 Jul 2012 09:12:00 EDT. Please see our terms for use of feeds.

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#Breitbart.com and Drudge Report: Center Right? Who Are They Kidding? (Little green footballs)

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Olympic Fever Boosting London Property Market - Oh No It Isn't

Analysts, commentators and pundits are in hot debate about whether or not the Olympics is having a positive impact on London property prices and/or the rental market, and whether it will have any effects down the line.

The debate pits two of the most prolific experts on the London property market on opposite sides. Savills' director of residential research Yolande Barnes and Knight Frank's opposite number Liam Bailey are usually pretty close in their predictions and commentaries on the capital (admittedly they mostly comment on prime central London), but they blatantly disagree on whether the Olympics can cause a boom in the east London property market.

Looking at Land Registry data we can see that the anticipated and predicted boom in house prices hasn't materialised. According to the data house prices rose 5.1% in London in the year to end April 2012, but in the borough of Newham home to the Olympic Park, prices moved up just 2% during the same period.

Bailey agrees there has been no boom. "If you look at data from the Land Registry, prices have not boomed in any way ? they have followed the regional pattern really," he says. But more importantly he says there will be no boom, not even in the rental market.

We have reports from sites like Homelet talking about the "Olympic Impact" as London rental prices grew by 7.1% in the year ending April, and by 8.6% in east London (an area which includes and extends beyond Newham).? Bailey blatantly disagrees with this:? "The Olympics doesn't really have any impact in terms of demand, the infrastructure is the main legacy," he says, instead citing London's growing population and the fact that housing in the east is more affordable to the growing thousands in need of houses to rent.

Meanwhile Barnes agrees that there has been no boom, but argues that it is only a matter of time as most of the new housing developments are yet to be completed. Until those developments conclude, it's too soon to look for an Olympic housing boom, said Barnes.

"You absolutely wouldn't expect to have seen one yet," Barnes said. "If you look at this as a regeneration project, regeneration projects only make a difference when they are finished not before they have taken place."

Barnes does expect to see an improvement in house prices and rental rates in the months following the Games, once the Olympic Park and Athletes village become open to the public. However, the improvement will likely be steady owing to the type of housing that will become available.

"There are prospects for rental growth in the longer term as it's where more ordinary Londoners are going to live. [Buyers] will increasingly be investors looking for high quality income streams," Barnes said.

There is even doubt over the heavily anticipated boom in high yield short term rentals. We have sites like HomeAway.co.uk reporting landlords fetching short term lets at rents 70% to 200% above the norm,? but others calling such reports hype and saying that such things will not happen often because of the thousands of properties on the market.

"There have been reports of astronomical rents and it's a lot of hype," says Joanne Doniger who runs AccommodateLondon.com. "I know that most companies with people working at the Olympics do not have great big budgets for luxury mansions and anyway, it's up to the guest because there is such a huge selection - it's a buyers' market."

Gumtree, which is a huge UK based classifieds site says that 2,321 ads posted for Olympic rentals between January and May and almost 10,500 replies to such posts. Based on that it would seem that demand is outstripping supply. However, looking at Gumtree now we can see that there are still thousands of properties remaining, which potentially means that renters have unrealistic expectations on what people are willing to pay.

Michael Banks, a director of London based lettings site Upad.co.uk also weighs in on the rental argument, saying any increase in rental rates will only be short-term, and is likely to affect other London boroughs as much as the eastern ones, as people from outside the city will seek to position themselves amidst other attractions offered by the capital. His statements on the potential for a boom in general though are particularly astute.

"There could be some long-term impact on the rental market in east London based on the investment in infrastructure, like the Westfield [Shopping] Centre, but it has nothing to do with 'brand Olympics'," Banks said. "If you look at other sporting stadia in London, like Wembley, the stadium does not increase the value in an area, it depresses it .... no one will pay extra to live there because the Olympics was there three years ago."

*This page is provided for information purposes only and should not be construed as offering advice. IPIN is not licensed to give financial advice and all information provided by IPIN regarding real estate should never be treated as specific advice or regulations. This is standard practice with property investment companies as the purchase of property as an investment is not regulated by the UK or other Financial Services Authorities.

Source: http://feeds.ipinglobal.com/~r/ipin-live/~3/EmP9nizOmgQ/olympic-fever-boosting-london-property-market--oh-no-it-isnt

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10% Guaranteed Income From This Florida Investment/holidayhome

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Source: http://www.arkadia.com/usa/real-estate/for-sale/united-states/florida/pinellas/clearwater/zpoc-t1777734/

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Mali: Islamists attack Timbuktu heritage sites

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Source: http://news.yahoo.com/mali-islamists-attack-timbuktu-heritage-sites-104354525.html

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Today on New Scientist: 29 June 2012

AI fantasy football manager picks a winning team

An artificial fantasy football manager has come in the top one per cent of players just by analysing statistics

Calling the next Trevor Baylis

Wind-up radios helped changed the developing world. The search is now on for similar cheap technologies to aid sustainable development, says Ulrike Wahl

Earth's oldest impact crater found in Greenland

A gigantic asteroid smashed into Greenland 3 billion years ago, making the crater it left behind the oldest on Earth - but the finding is controversial

Giant living power cables let bacteria respire

Bacteria living in sulphur-rich mud respire by organising themselves into living power cables

Cyborg makes art using seventh sense

Meet the colour-blind man with a prosthetic eyepiece that allows him to "see" colours as sounds - and create unique artworks out of them

Shaking metallic grains turns them into tunable laser

The unorthodox laser could lead to crisper medical images and help unlock the mysterious behaviour of granular materials such as sand dunes and avalanches

Wanna be the leader? You gotta have friends

Macaque groups simply follow their mates, so the macaque with the best connections automatically becomes leader

World's thinnest screen created from soap bubble

See a new display made from soap film that can mimic different textures and create vivid 3D projections

Feedback: Uncertain in Llanfair PG

Hamster weight wanting, heights of absurdity, new fossil surprise, and more

Praying mantis bot has extra-nimble legs

A robot limb based on the versatile forelegs of the praying mantis could be used to walk, grab objects and manipulate them

Does solitary confinement breach the Eighth Amendment?

As a US congressional hearing considers whether solitary confinement constitutes cruel and unusual punishment, evidence of its psychological damage grows

Don't fence us in: Modern-day land grabs

From Midwest "missionaries" to Wall Street speculators, investors are grabbing massive swathes of common land, says Fred Pearce, especially in Africa

TV and radio signals take over when GPS goes wrong

The broadcast signals we take for granted can provide a very effective backup for the global positioning system

First private space telescope may hunt asteroids

The non-profit B612 Foundation announced plans today to launch a space telescope later this decade that will search for dangerous asteroids

Oldest pottery hints at cooking's ice-age origins

Fragments of pots from a Chinese cave are 20,000 years old, and may have been used to cook food during the depths of the last ice age

Titan's tides reveal hidden ocean that could host life

Combined with its organic resources, abundant liquid water could make Saturn's moon prime real estate for alien life - but that depends on the state of the ocean

Zoologger: Fish with elephant's nose and crystal eyes

Peters' elephantnose fish doesn't just have a trunk that detects electric fields, it has bizarre eyes that have adapted to its murky lifestyle

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